ADAM8

ADAM8
ADAM8
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 4DD8
Идентификаторы
Символ	ADAM8 ; CD156; CD156a; MS2
Внешние ID	OMIM: 602267 MGI: 107825 HomoloGene: 74384 GeneCards: Ген ADAM8
номер EC	3.4.24.-
Функция	• metalloendopeptidase activity; • calcium ion binding; • protein binding; • metallopeptidase activity; • zinc ion binding; • protein self-association; • cell adhesion molecule binding;
Компонент клетки	• podosome; • cytoplasm; • plasma membrane; • integral component of plasma membrane; • cell surface; • phagolysosome; • dense core granule membrane; • specific granule; • tertiary granule; • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; • alpha9-beta1 integrin-ADAM8 complex;
Биологический процесс	• cell morphogenesis; • angiogenesis; • leukocyte migration involved in inflammatory response; • positive regulation of acute inflammatory response; • proteolysis; • inflammatory response; • positive regulation of protein processing; • single organismal cell-cell adhesion; • regulation of cell-cell adhesion; • extracellular matrix disassembly; • extracellular matrix organization; • positive regulation of T cell differentiation in thymus; • activation of MAPK activity involved in innate immune response; • negative regulation of neuron apoptotic process; • positive regulation of bone resorption; • positive regulation of cell adhesion; • lymphocyte chemotaxis; • positive regulation of protein secretion; • positive regulation of membrane protein ectodomain proteolysis; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of protein kinase B signaling; • positive regulation of thymocyte apoptotic process; • cellular response to hypoxia; • positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; • positive regulation of neutrophil extravasation; • positive regulation of fibronectin-dependent thymocyte migration; • positive regulation of eosinophil migration;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

ADAM8 (англ. A Disintegrin And Metalloproteinase domain 8; CD156a) — фермент металлопротеаза, относящийся к семейству металлопротеаз ADAM. Продукт гена человека ADAM8.^[1]^[2]

↑ Yoshiyama K., Higuchi Y., Kataoka M., Matsuura K., Yamamoto S. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location (англ.) // Genomics : journal. — Academic Press, 1997. — May (vol. 41, no. 1). — P. 56—62. — doi:10.1006/geno.1997.4607. — PMID 9126482.
↑ Entrez Gene: ADAM8 ADAM metallopeptidase domain 8 (неопр.).

[pmid9126482-1] Yoshiyama K., Higuchi Y., Kataoka M., Matsuura K., Yamamoto S. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location (англ.) // Genomics : journal. — Academic Press, 1997. — May (vol. 41, no. 1). — P. 56—62. — doi:10.1006/geno.1997.4607. — PMID 9126482.

[entrez-2] Entrez Gene: ADAM8 ADAM metallopeptidase domain 8 (неопр.).

[1]

[2]